Liquid biopsies: noninvasive longitudinal monitoring of lung cancer
نویسندگان
چکیده
منابع مشابه
Liquid biopsies transform lung cancer therapy
This article was written by Dr Lukas C Heukamp, medical director of NEO New Oncology AG in Cologne, Germany, [email protected]. Understanding how genetic alterations drive tumour growth and progression in virtually all cancer indications is revolutionising cancer treatment. Modern medicine takes advantage of the weak points of a tumour by developing so-called targeted drugs. In lung cancer, m...
متن کاملALK Status Assessment with Liquid Biopsies of Lung Cancer Patients
Patients with advanced stage non-small cell lung carcinoma (NSCLC) harboring an anaplastic lymphoma kinase ALK gene rearrangement, detected from a tissue sample, can benefit from targeted ALK inhibitor treatment. However, while treatment is initially effective in most cases, relapse or progression occurs due to different resistance mechanisms including mutations in the tyrosine kinase domain of...
متن کاملLiquid biopsies for bladder cancer
The development of accurate urinary biomarkers for the non-invasive detection of urothelial bladder cancer (UBC) could transform patient pathways by reducing reliance on cystoscopy, and the identification of highly prognostic (or even predictive) biomarkers could better guide patient management. A number of approaches are being utilised to address these challenges in both urinary- and plasma-bo...
متن کاملMolecular profile of liquid biopsies: next generation biomarkers to improve lung cancer treatment
Molecular profiling of liquid biopsies is now emerging as pivotal for cancer biomarker discovery. The low-invasive nature of the approach used for collecting biospecimens (i.e. blood, urine, saliva, etc.) may allow a widespread application of novel molecular diagnostics based on liquid biopsies. This is relevant, for example, in cancer screening programmes where it is essential to reduce costs ...
متن کاملMolecular profiling of lung cancer specimens and liquid biopsies using MALDI-TOF mass spectrometry.
BACKGROUND Identification of predictive molecular alterations in lung adenocarcinoma is essential for accurate therapeutic decisions. Although several molecular approaches are available, a number of issues, including tumor heterogeneity, frequent material scarcity, and the large number of loci to be investigated, must be taken into account in selecting the most appropriate technique. MALDI-TOF ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2015
ISSN: 0923-7534
DOI: 10.1093/annonc/mdv409.02